Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

Base excision repair (BER) is the major cellular pathway involved in removal of endogenous/spontaneous DNA lesions. Here, we study the mechanism that controls the steady-state levels of BER enzymes in human cells. By fractionating human cell extract, we purified the E3 ubiquitin ligase Mule (ARF-BP1...

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Autors principals: Parsons, Jason L, Tait, Phillip S, Finch, David, Dianova, Irina I, Edelmann, Mariola J, Khoronenkova, Svetlana V, Kessler, Benedikt M, Sharma, Ricky A, McKenna, W Gillies, Dianov, Grigory L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771081/
https://ncbi.nlm.nih.gov/pubmed/19713937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.243
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