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Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress
We examined the mechanism regulating the cellular levels of PNKP, the major kinase/phosphatase involved in the repair of oxidative DNA damage, and find that it is controlled by ATM phosphorylation and ubiquitylation-dependent proteasomal degradation. We discovered that ATM-dependent phosphorylation...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526271/ https://ncbi.nlm.nih.gov/pubmed/23042680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks909 |
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