Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

We examined the mechanism regulating the cellular levels of PNKP, the major kinase/phosphatase involved in the repair of oxidative DNA damage, and find that it is controlled by ATM phosphorylation and ubiquitylation-dependent proteasomal degradation. We discovered that ATM-dependent phosphorylation...

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Главные авторы: Parsons, Jason L., Khoronenkova, Svetlana V., Dianova, Irina I., Ternette, Nicola, Kessler, Benedikt M., Datta, Pran K., Dianov, Grigory L.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526271/
https://ncbi.nlm.nih.gov/pubmed/23042680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks909
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