Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

We examined the mechanism regulating the cellular levels of PNKP, the major kinase/phosphatase involved in the repair of oxidative DNA damage, and find that it is controlled by ATM phosphorylation and ubiquitylation-dependent proteasomal degradation. We discovered that ATM-dependent phosphorylation...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Parsons, Jason L., Khoronenkova, Svetlana V., Dianova, Irina I., Ternette, Nicola, Kessler, Benedikt M., Datta, Pran K., Dianov, Grigory L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526271/
https://ncbi.nlm.nih.gov/pubmed/23042680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks909
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars