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Regulation of Human MutYH DNA Glycosylase by the E3 Ubiquitin Ligase Mule

Oxidation of DNA is a frequent and constantly occurring event. One of the best characterized oxidative DNA lesions is 7,8-dihydro-8-oxoguanine (8-oxo-G). It instructs most DNA polymerases to preferentially insert an adenine (A) opposite 8-oxo-G instead of the appropriate cytosine (C) thus showing mi...

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Detalhes bibliográficos
Main Authors: Dorn, Julia, Ferrari, Elena, Imhof, Ralph, Ziegler, Nathalie, Hübscher, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945365/
https://ncbi.nlm.nih.gov/pubmed/24443563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536094
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