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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA

Maintenance of genetic stability is crucial for all organisms in order to avoid the onset of deleterious diseases such as cancer. One of the many proveniences of DNA base damage in mammalian cells is oxidative stress, arising from a variety of endogenous and exogenous sources, generating highly muta...

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Detalhes bibliográficos
Main Authors: Markkanen, Enni, Dorn, Julia, Hübscher, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584444/
https://ncbi.nlm.nih.gov/pubmed/23450852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00018
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