Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection

Vascular endothelium is vulnerable to the attack of glucose-derived oxoaldehydes (glyoxal and methylglyoxal) during diabetes, through the formation of advanced glycation end products (AGEs). Although aminoguanidine (AG) has been shown to protect against the AGE-induced adverse effects, its protectio...

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Autori principali: Sliman, Sean M., Eubank, Timothy D., Kotha, Sainath R., Kuppusamy, M. Lakshmi, Sherwani, Shariq I., O’Connor Butler, Elizabeth Susan, Kuppusamy, Periannan, Roy, Sashwati, Marsh, Clay B., Stern, David M., Parinandi, Narasimham L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671881/
https://ncbi.nlm.nih.gov/pubmed/19585224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-009-0199-x
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