Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection

Vascular endothelium is vulnerable to the attack of glucose-derived oxoaldehydes (glyoxal and methylglyoxal) during diabetes, through the formation of advanced glycation end products (AGEs). Although aminoguanidine (AG) has been shown to protect against the AGE-induced adverse effects, its protectio...

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Autors principals: Sliman, Sean M., Eubank, Timothy D., Kotha, Sainath R., Kuppusamy, M. Lakshmi, Sherwani, Shariq I., O’Connor Butler, Elizabeth Susan, Kuppusamy, Periannan, Roy, Sashwati, Marsh, Clay B., Stern, David M., Parinandi, Narasimham L.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671881/
https://ncbi.nlm.nih.gov/pubmed/19585224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-009-0199-x
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