Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A(2), lipoxygenase, and cyclooxygenase

We have earlier reported that the redox-active antioxidant, vitamin C (ascorbic acid), activates the lipid signaling enzyme, phospholipase D (PLD), at pharmacological doses (mM) in the bovine lung microvascular endothelial cells (BLMVECs). However, the activation of phospholipase A(2) (PLA(2)), anot...

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Veröffentlicht in:Mol Cell Biochem
Hauptverfasser: Steinhour, Emily, Sherwani, Shariq I., Mazerik, Jessica N., Ciapala, Valorie, Butler, Elizabeth O’Connor, Cruff, Jason P., Magalang, Ulysses, Parthasarathy, Sampath, Sen, Chandan K., Marsh, Clay B., Kuppusamy, Periannan, Parinandi, Narasimham L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067108/
https://ncbi.nlm.nih.gov/pubmed/18496733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-008-9793-6
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