Pulmonary Fibrosis Inducer, Bleomycin, Causes Redox-Sensitive Activation of Phospholipase D and Cytotoxicity Through Formation of Bioactive Lipid Signal Mediator, Phosphatidic Acid, in Lung Microvascular Endothelial Cells

The mechanisms of lung microvascular complications and pulmonary hypertension known to be associated with idiopathic pulmonary fibrosis (IPF), a debilitating lung disease, are not known. Therefore, we investigated whether bleomycin, the widely used experimental IPF inducer, would be capable of activ...

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Main Authors: Patel, Rishi B., Kotha, Sainath R., Sherwani, Shariq I., Sliman, Sean M., Gurney, Travis O., Loar, Brooke, Butler, Susan O’Connor, Morris, Andrew J., Marsh, Clay B., Parinandi, Narasimham L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503147/
https://ncbi.nlm.nih.gov/pubmed/21131602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1091581810388850
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