Novel Lipid-Soluble Thiol-Redox Antioxidant and Heavy Metal Chelator, N,N′-bis(2-Mercaptoethyl)Isophthalamide (NBMI) and Phospholipase D-Specific Inhibitor, 5-Fluoro-2-Indolyl Des-Chlorohalopemide (FIPI) Attenuate Mercury-Induced Lipid Signaling Leading to Protection Against Cytotoxicity in Aortic Endothelial Cells

Here, we investigated thiol-redox-mediated phospholipase D (PLD) signaling as a mechanism of mercury cytotoxicity in mouse aortic endothelial cell (MAEC) in vitro model utilizing the novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N′-bis(2-mercaptoethyl)isophthalamide (NBMI)...

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Main Authors: Secor, Jordan D., Kotha, Sainath R., Gurney, Travis O., Patel, Rishi B., Kefauver, Nicholas R., Gupta, Niladri, Morris, Andrew J., Haley, Boyd E., Parinandi, Narasimham L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503146/
https://ncbi.nlm.nih.gov/pubmed/21994240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1091581811422413
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