5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is in...

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Main Authors: Su, Wenjuan, Yeku, Oladapo, Olepu, Srinivas, Genna, Alyssa, Park, Jae-Sook, Ren, Hongmei, Du, Guangwei, Gelb, Michael H., Morris, Andrew J., Frohman, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Pharmacology and Experimental Therapeutics 2009
Teme:
Accelerated Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684902/
https://ncbi.nlm.nih.gov/pubmed/19064628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053298
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