5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is in...

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Detalhes bibliográficos
Main Authors: Su, Wenjuan, Yeku, Oladapo, Olepu, Srinivas, Genna, Alyssa, Park, Jae-Sook, Ren, Hongmei, Du, Guangwei, Gelb, Michael H., Morris, Andrew J., Frohman, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Accelerated Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684902/
https://ncbi.nlm.nih.gov/pubmed/19064628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053298
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