5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is in...

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Autores principales: Su, Wenjuan, Yeku, Oladapo, Olepu, Srinivas, Genna, Alyssa, Park, Jae-Sook, Ren, Hongmei, Du, Guangwei, Gelb, Michael H., Morris, Andrew J., Frohman, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
Materias:
Accelerated Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684902/
https://ncbi.nlm.nih.gov/pubmed/19064628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053298
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