Sulfaphenazole Protects Heart Against Ischemia–Reperfusion Injury and Cardiac Dysfunction by Overexpression of iNOS, Leading to Enhancement of Nitric Oxide Bioavailability and Tissue Oxygenation

The objective of this study was to establish the cardioprotective effect of sulfaphenazole (SPZ), a selective inhibitor of cytochrome P450 2C9 enzyme, in an in vivo rat model of acute myocardial infarction (MI). MI was induced by 30 min ligation of left anterior descending coronary artery, followed...

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Detalhes bibliográficos
Main Authors: Khan, Mahmood, Mohan, Iyyapu K., Kutala, Vijay K., Kotha, Sainath R., Parinandi, Narasimham L., Hamlin, Robert L., Kuppusamy, Periannan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850300/
https://ncbi.nlm.nih.gov/pubmed/18855521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2008.2155
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