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PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

The inhibitory receptor programmed cell death 1 (PD-1) plays a major role in functional exhaustion of T cells during chronic infections and cancer, and recent clinical data suggest that blockade of the PD-1 pathway is an effective immunotherapy in treating certain cancers. Thus, it is important to d...

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Main Authors: West, Erin E., Jin, Hyun-Tak, Rasheed, Ata-Ur, Penaloza-MacMaster, Pablo, Ha, Sang-Jun, Tan, Wendy G., Youngblood, Ben, Freeman, Gordon J., Smith, Kendall A., Ahmed, Rafi
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668811/
https://ncbi.nlm.nih.gov/pubmed/23676462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67008
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