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4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection

Previous studies have identified the inhibitory role that the programmed death 1 (PD-1) pathway plays during chronic infection. Blockade of this pathway results in rescue of viral-specific CD8 T cells, as well as reduction of viral loads in mice chronically infected with lymphocytic choriomeningitis...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Vezys, Vaiva, Penaloza-MacMaster, Pablo, Barber, Daniel L., Ha, Sang-Jun, Konieczny, Bogumila, Freeman, Gordon J., Mittler, Robert S., Ahmed, Rafi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404506/
https://ncbi.nlm.nih.gov/pubmed/21742975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100077
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