Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS

Amyotrophic lateral sclerosis is the most common motor neuron disease and is still incurable. The mechanisms leading to the selective motor neuron vulnerability are still not known. The interplay between motor neurons and astrocytes is crucial in the outcome of the disease. We show that mutant coppe...

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Hlavní autoři: Basso, Manuela, Pozzi, Silvia, Tortarolo, Massimo, Fiordaliso, Fabio, Bisighini, Cinzia, Pasetto, Laura, Spaltro, Gabriella, Lidonnici, Dario, Gensano, Francesco, Battaglia, Elisa, Bendotti, Caterina, Bonetto, Valentina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668729/
https://ncbi.nlm.nih.gov/pubmed/23592792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425066
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