Palmitoylation of Superoxide Dismutase 1 (SOD1) Is Increased for Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants

Mutations in Cu,Zn-superoxide dismutase (mtSOD1) cause familial amyotrophic lateral sclerosis (FALS), a neurodegenerative disease resulting from motor neuron degeneration. Here, we demonstrate that wild type SOD1 (wtSOD1) undergoes palmitoylation, a reversible post-translational modification that ca...

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Autors principals: Antinone, Sarah E., Ghadge, Ghanashyam D., Lam, Tukiet T., Wang, Lijun, Roos, Raymond P., Green, William N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724620/
https://ncbi.nlm.nih.gov/pubmed/23760509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.487231
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