Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection

Mutations in human Cu/Zn superoxide dismutase-1 (SOD) cause ∼20% of cases of familial amyotrophic lateral sclerosis (FALS). We investigated the mechanism of mutant SOD-induced neuronal degeneration by expressing wild-type and mutant SODs in neuronal cells by means of infection with replication-defic...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ghadge, G. D., Lee, J. P., Bindokas, V. P., Jordan, J., Ma, L., Miller, R. J., Roos, R. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573090/
https://ncbi.nlm.nih.gov/pubmed/9348345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-22-08756.1997
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