Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes: A POSSIBLE ROLE IN AMYOTROPHIC LATERAL SCLEROSIS

Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest nearly every amino acid residue in SOD1 is dynamically connected to the dimer interface. Post-translational modifica...

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Bibliografische gegevens
Hoofdauteurs: Wilcox, Kyle C., Zhou, Li, Jordon, Joshua K., Huang, Yi, Yu, Yanbao, Redler, Rachel L., Chen, Xian, Caplow, Michael, Dokholyan, Nikolay V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
Onderwerpen:
Protein Structure and Folding
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679493/
https://ncbi.nlm.nih.gov/pubmed/19299510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809687200
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