Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes: A POSSIBLE ROLE IN AMYOTROPHIC LATERAL SCLEROSIS

Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest nearly every amino acid residue in SOD1 is dynamically connected to the dimer interface. Post-translational modifica...

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Bibliografiske detaljer
Main Authors: Wilcox, Kyle C., Zhou, Li, Jordon, Joshua K., Huang, Yi, Yu, Yanbao, Redler, Rachel L., Chen, Xian, Caplow, Michael, Dokholyan, Nikolay V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679493/
https://ncbi.nlm.nih.gov/pubmed/19299510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809687200
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