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The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis

Mutant superoxide dismutase type 1 (MTSOD1), the most common known cause of familial amyotrophic lateral sclerosis (FALS), is believed to cause FALS as a result of a toxicity of the protein. MTSOD1s with full dismutase enzymatic activity (e.g., G37R) and without any enzymatic activity (e.g., G85R) c...

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Detalhes bibliográficos
Main Authors: Wang, Lijun, Sharma, Kamal, Grisotti, Gabriella, Roos, Raymond P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706919/
https://ncbi.nlm.nih.gov/pubmed/19442735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.05.002
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