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The unfolded protein response in familial amyotrophic lateral sclerosis
Mutant superoxide dismutase type 1 (MTSOD1) is thought to cause ∼20% of cases of familial amyotrophic lateral sclerosis (FALS) because it misfolds and aggregates. Previous studies have shown that MTSOD1 accumulates inside the endoplasmic reticulum (ER) and activates the unfolded protein response (UP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033190/ https://ncbi.nlm.nih.gov/pubmed/21159797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq546 |
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