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The unfolded protein response in familial amyotrophic lateral sclerosis
Mutant superoxide dismutase type 1 (MTSOD1) is thought to cause ∼20% of cases of familial amyotrophic lateral sclerosis (FALS) because it misfolds and aggregates. Previous studies have shown that MTSOD1 accumulates inside the endoplasmic reticulum (ER) and activates the unfolded protein response (UP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033190/ https://ncbi.nlm.nih.gov/pubmed/21159797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq546 |
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