Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic Drosophila

A subset of patients suffering from familial amyotrophic lateral sclerosis (FALS) exhibit point mutations in the gene encoding Cu-Zn superoxide dismutase [superoxide:superoxide oxidoreductase, EC 1.15.1.1 (SOD)]. The human wild-type and five FALS Sod mutant transgenes were introduced into the fruit...

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Bibliografiske detaljer
Main Authors: Mockett, Robin J., Radyuk, Svetlana N., Benes, Judith J., Orr, William C., Sohal, Rajindar S.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140958/
https://ncbi.nlm.nih.gov/pubmed/12502789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0136976100
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