Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

Human leukocyte antigen (HLA)-I molecules can present long peptides, yet the mechanisms by which T-cell receptors (TCRs) recognize featured pHLA-I landscapes are unclear. We compared the binding modes of three distinct human TCRs, CA5, SB27, and SB47, complexed with a “super-bulged” viral peptide (L...

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Detalhes bibliográficos
Main Authors: Liu, Yu Chih, Miles, John J., Neller, Michelle A., Gostick, Emma, Price, David A., Purcell, Anthony W., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, Gras, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668706/
https://ncbi.nlm.nih.gov/pubmed/23569211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447185
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