Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.
We have isolated overlapping recombinant cosmids that represent 150 kilobases of contiguous DNA sequence from the amplified dihydrofolate reductase domain of a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400). This sequence includes the 25-kilobase dihydrofolate reductase gene and a...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1985
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC366762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2985962/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.5.4.619-627.1985 |
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