Physiologic Concentrations of Exogenously Infused Ghrelin Reduces Insulin Secretion Without Affecting Insulin Sensitivity in Healthy Humans

BACKGROUND: Infusion of ghrelin to supraphysiologic levels inhibits glucose-stimulated insulin secretion, reduces insulin sensitivity, and worsens glucose tolerance in humans. OBJECTIVE: The purpose of this study was to determine the effects of lower doses of ghrelin on insulin secretion and insulin...

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Bibliographic Details
Main Authors: Tong, Jenny, Prigeon, Ronald L., Davis, Harold W., Bidlingmaier, Martin, Tschöp, Matthias H., D'Alessio, David
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
Subjects:
Endocrine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667259/
https://ncbi.nlm.nih.gov/pubmed/23589527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-4162
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