Ghrelin Stimulation of Growth Hormone Isoforms: Parallel Secretion of Total and 20-kDa Growth Hormone and Relation to Insulin Sensitivity in Healthy Humans

CONTEXT: The 20-kDa human GH (hGH) is produced in the pituitary by alternative splicing of the hGH-N gene. The 20-kDa hGH promotes growth similarly to 22-kDa or total hGH, the predominant form in circulation, but the relative effects of these isoforms on glucose metabolism have been debated. OBJECTI...

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Bibliografiske detaljer
Main Authors: Tong, Jenny, D'Alessio, David, Ramisch, Juliane, Davis, Harold W., Stambrook, Elizabeth, Tschöp, Matthias H., Bidlingmaier, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2012
Fag:
Endocrine Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431574/
https://ncbi.nlm.nih.gov/pubmed/22745239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2012
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