Physiologic Concentrations of Exogenously Infused Ghrelin Reduces Insulin Secretion Without Affecting Insulin Sensitivity in Healthy Humans

BACKGROUND: Infusion of ghrelin to supraphysiologic levels inhibits glucose-stimulated insulin secretion, reduces insulin sensitivity, and worsens glucose tolerance in humans. OBJECTIVE: The purpose of this study was to determine the effects of lower doses of ghrelin on insulin secretion and insulin...

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Hlavní autoři: Tong, Jenny, Prigeon, Ronald L., Davis, Harold W., Bidlingmaier, Martin, Tschöp, Matthias H., D'Alessio, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2013
Témata:
Endocrine Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667259/
https://ncbi.nlm.nih.gov/pubmed/23589527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-4162
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