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Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third leading cause of cancer death worldwide. The only approved systemic treatment for unresectable HCC is the oral kinase inhibitor, sorafenib. Recombinant human acid sphingomyelinase (rhASM), which hydrolyz...

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Autori principali: Savić, Radoslav, He, Xingxuan, Fiel, Isabel, Schuchman, Edward H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665770/
https://ncbi.nlm.nih.gov/pubmed/23724146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065620
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