Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

In Alzheimer’s disease (AD), abnormal sphingolipid metabolism has been reported, although the pathogenic consequences of these changes have not been fully characterized. We show that acid sphingomyelinase (ASM) is increased in fibroblasts, brain, and/or plasma from patients with AD and in AD mice, l...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Jong Kil, Jin, Hee Kyung, Park, Min Hee, Kim, Bo-ra, Lee, Phil Hyu, Nakauchi, Hiromitsu, Carter, Janet E., He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113944/
https://ncbi.nlm.nih.gov/pubmed/25049335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132451
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