Kinase scaffold repurposing for neglected disease drug discovery: Discovery of an efficacious, lapatanib-derived lead compound for trypanosomiasis

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Since drugs in use against HAT are toxic and require intravenous dosing, new drugs are needed. Initiating lead discovery campaigns by using chemical scaffolds from drugs approved...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Patel, Gautam, Karver, Caitlin E., Behera, Ranjan, Guyett, Paul, Sullenberger, Catherine, Edwards, Peter, Roncal, Norma E., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663906/
https://ncbi.nlm.nih.gov/pubmed/23597080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400349k
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