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Kinase scaffold repurposing for neglected disease drug discovery: Discovery of an efficacious, lapatanib-derived lead compound for trypanosomiasis

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Since drugs in use against HAT are toxic and require intravenous dosing, new drugs are needed. Initiating lead discovery campaigns by using chemical scaffolds from drugs approved...

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Bibliografske podrobnosti
Main Authors:	Patel, Gautam, Karver, Caitlin E., Behera, Ranjan, Guyett, Paul, Sullenberger, Catherine, Edwards, Peter, Roncal, Norma E., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Format:	Artigo
Jezik:	Inglês
Izdano:	2013
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3663906/ https://ncbi.nlm.nih.gov/pubmed/23597080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400349k
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Kinase scaffold repurposing for neglected disease drug discovery: Discovery of an efficacious, lapatanib-derived lead compound for trypanosomiasis

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