The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

BACKGROUND: It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-2/Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. We designed the BH3 α-helix mimetic JY-1-106 to engage the hydrophobic BH3-binding grooves on the sur...

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Detalhes bibliográficos
Main Authors: Cao, Xiaobo, Yap, Jeremy L, Newell-Rogers, M Karen, Peddaboina, Chander, Jiang, Weihua, Papaconstantinou, Harry T, Jupitor, Dan, Rai, Arun, Jung, Kwan-Young, Tubin, Richard P, Yu, Wenbo, Vanommeslaeghe, Kenno, Wilder, Paul T, MacKerell, Alexander D, Fletcher, Steven, Smythe, Roy W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663763/
https://ncbi.nlm.nih.gov/pubmed/23680104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-42
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