The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

BACKGROUND: It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. Mcl-1 is a critical survival protein in a variety of cell lineages and is critically regulated via ubiquiti...

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Main Authors: Peddaboina, Chander, Jupiter, Daniel, Fletcher, Steven, Yap, Jeremy L, Rai, Arun, Tobin, Richard P, Jiang, Weihua, Rascoe, Philip, Rogers, M Karen Newell, Smythe, W Roy, Cao, Xiaobo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543233/
https://ncbi.nlm.nih.gov/pubmed/23171055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-541
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