EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY

The purpose of this study was to examine whether inhibition of RAC1 would enhance the pro-apoptotic reprogramming of glioblastoma’s cellular circuitry following selective Bcl-2/Bcl-xL inhibition by BH-3 mimetics. Preclinical drug testing and molecular profiling was performed in different glioblastom...

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Foilsithe in:Neuro Oncol
Main Authors: Hlavac, Michal, Dwucet, Annika, Westhoff, Mike-Andrew, Kast, Richard Eric, Engelke, Jens, Siegelin, Markus, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Georg
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2018
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Abstracts
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217454/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.403
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