EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY

The purpose of this study was to examine whether inhibition of RAC1 would enhance the pro-apoptotic reprogramming of glioblastoma’s cellular circuitry following selective Bcl-2/Bcl-xL inhibition by BH-3 mimetics. Preclinical drug testing and molecular profiling was performed in different glioblastom...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Hlavac, Michal, Dwucet, Annika, Westhoff, Mike-Andrew, Kast, Richard Eric, Engelke, Jens, Siegelin, Markus, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Georg
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217454/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.403
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller