Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

Despite great efforts taken to advance therapeutic measures for patients with glioblastoma, the clinical prognosis remains grim. The antiapoptotic Bcl-2 family protein Mcl-1 is overexpressed in glioblastoma and represents an important resistance factor to the BH-3 mimetic ABT263. In this study, we s...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Karpel-Massler, Georg, Shu, Chang, Chau, Lily, Banu, Matei, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Ramirez, Yulian, Ross, Alonzo H., Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546483/
https://ncbi.nlm.nih.gov/pubmed/26008975
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