Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads to the production of the oncometabolite 2-R-2-hydroxyglutarate (2-HG). In six model systems, including patient-derived stem cell-like glioblastoma cultures, inhibition of Bcl-xL induces significantly more apo...

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Publicado no:Nat Commun
Main Authors: Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Bianchetti, Elena, Zhang, Yiru, Shu, Chang, Tsujiuchi, Takashi, Banu, Matei A., Garcia, Franklin, Roth, Kevin A., Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651864/
https://ncbi.nlm.nih.gov/pubmed/29057925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00984-9
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