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Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition
Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 a...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | EMBO Mol Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6783693/ https://ncbi.nlm.nih.gov/pubmed/31468706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910769 |
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