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Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 a...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EMBO Mol Med
Κύριοι συγγραφείς: Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhang, Yiru, Bianchetti, Elena, Sanchez‐Quintero, Maria J, Kleiner, Giulio, Quinzii, Catarina M, Westhoff, Mike‐Andrew, Karpel‐Massler, Georg, Canoll, Peter, Siegelin, Markus D
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783693/
https://ncbi.nlm.nih.gov/pubmed/31468706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910769
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