Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 a...

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Publicat a:EMBO Mol Med
Autors principals: Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhang, Yiru, Bianchetti, Elena, Sanchez‐Quintero, Maria J, Kleiner, Giulio, Quinzii, Catarina M, Westhoff, Mike‐Andrew, Karpel‐Massler, Georg, Canoll, Peter, Siegelin, Markus D
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783693/
https://ncbi.nlm.nih.gov/pubmed/31468706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910769
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