Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 a...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhang, Yiru, Bianchetti, Elena, Sanchez‐Quintero, Maria J, Kleiner, Giulio, Quinzii, Catarina M, Westhoff, Mike‐Andrew, Karpel‐Massler, Georg, Canoll, Peter, Siegelin, Markus D
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783693/
https://ncbi.nlm.nih.gov/pubmed/31468706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910769
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