Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults. However, given that tumors become commonly resistant to single treatments, the identification of combination therapies is critical. Th...

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Pubblicato in:Sci Rep
Autori principali: Shang, Enyuan, Zhang, Yiru, Shu, Chang, Ishida, Chiaki Tsuge, Bianchetti, Elena, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194027/
https://ncbi.nlm.nih.gov/pubmed/30337641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33784-2
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