Bcl-xL inhibition - a novel strategy for glioma therapy

Por Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Aging (Albany NY) (2016)

TIC10/ONC201—a potential therapeutic in glioblastoma

Por Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Transl Cancer Res (2017)

A triple drug combination as a novel anti-glioma therapy?

Por Zhang, Yiru, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Oncotarget (2018)

BET-inhibitors as sensitizers for BH3-mimetics

Por Ishida, Chiaki Tsuge, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Aging (Albany NY) (2017)

IDH1 R132H predicts sensitivity to Bcl-xL inhibition-mediated programmed cell death

Por Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Siegelin, Markus D.
Publicado no Oncotarget (2017)

CBMT-37. FDA-APPROVED HDAC INHIBITORS ANTAGONIZE THE WARBURG EFFECT AND CAUSE UNIQUE METABOLIC VULNERABILITIES

Por Zhang, Yiru, Ishida, Chiaki, Karpel-Massler, Georg, Siegelin, Markus
Publicado no Neuro Oncol (2018)

Hsp60 REGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE IN TUMOR CELLS

Por Ghosh, Jagadish C., Siegelin, Markus D., Dohi, Takehiko, Altieri, Dario C.
Publicado em 2010

ET-26 COMBINED TREATMENT WITH ABT263 AND GX15-070 YIELDS A SYNERGISTIC ANTIPROLIFERATIVE EFFECT IN GLIOBLASTOMA

Por Karpel-Massler, Georg, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Siegelin, Markus David
Publicado em 2014

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

Por Siegelin, Markus D., Reuss, David E., Habel, Antje, Rami, Abdelhaq, von Deimling, Andreas
Publicado em 2009

Sorafenib exerts anti-glioma activity in vitro and in vivo

Por Siegelin, Markus D., Raskett, Christopher M., Gilbert, Candace A., Ross, Alonzo H., Altieri, Dario C.
Publicado em 2010

EXTH-45. THE REPURPOSED CUSP9 REGIMEN EXERTS POTENT ANTI-NEOPLASTIC ACTIVITY AGAINST GLIOBLASTOMA CELLS IN VITRO

Por Halatsch, Marc-Eric, Kast, Richard Eric, Dwucet, Annika, Siegelin, Markus, Heiland, Tim, Karpel-Massler, Georg
Publicado no Neuro Oncol (2018)

EXTH-54. Bcl-2/Bcl-xL INHIBITION SYNERGISTICALLY ENHANCES THE ANTI-NEOPLASTIC ACTIVITY OF CUSP9 AGAINST GLIOBLASTOMA CELLS IN VITRO

Por Halatsch, Marc-Eric, Kast, Richard Eric, Dwucet, Annika, Wirtz, Christian Rainer, Siegelin, Markus, Karpel-Massler, Georg
Publicado no Neuro Oncol (2018)

GLOBAL TARGETING OF SUBCELLULAR Hsp90 NETWORKS FOR THERAPY OF GLIOBLASTOMA*

Por Siegelin, Markus D., Plescia, Janet, Raskett, Christopher M., Gilbert, Candace A., Ross, Alonzo H., Altieri, Dario C.
Publicado em 2010

Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma

Por Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Zhang, Yiru, Halatsch, Marc-Eric, Westhoff, M.-Andrew, Siegelin, Markus D.
Publicado no Expert Opin Drug Discov (2017)

EXTH-64. IMIPRIDONES CAUSE METABOLIC REPROGRAMMING AND ELICIT UNIQUE VULNERABILITIES IN PRECLINICAL MODEL SYSTEMS OF GLIOBLASTOMA

Por Ishida, Chiaki, Zhang, Yiru, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Prabhu, Varun Vijay, Allen, Joshua, Siegelin, Markus
Publicado no Neuro Oncol (2018)

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma

Por Ishida, Chiaki Tsuge, Bianchetti, Elena, Shu, Chang, Halatsch, Marc-Eric, Westhoff, M. Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Oncotarget (2017)

Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors

Por Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Bianchetti, Elena, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Cancers (Basel) (2019)

Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma

Por Ishida, Chiaki Tsuge, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Altieri, Dario C., Karpel-Massler, Georg, Siegelin, Markus David
Publicado no Oncotarget (2017)

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

Por Shang, Enyuan, Zhang, Yiru, Shu, Chang, Ishida, Chiaki Tsuge, Bianchetti, Elena, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado no Sci Rep (2018)

TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

Por Karpel-Massler, Georg, Bâ, Maïmouna, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Publicado no Oncotarget (2015)