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EXTH-64. IMIPRIDONES CAUSE METABOLIC REPROGRAMMING AND ELICIT UNIQUE VULNERABILITIES IN PRECLINICAL MODEL SYSTEMS OF GLIOBLASTOMA
The purpose of this study is to improve the efficacy of imipridones, a novel class of AKT/ERK inhibitors. The lead compound ONC201 has entered clinical testing for glioblastoma (GBM) and recently chemically modified imipridones, ONC206 and ONC212, have been designed. Transcriptome, untargeted liquid...
Tallennettuna:
| Julkaisussa: | Neuro Oncol |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216202/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.411 |
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