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EXTH-64. IMIPRIDONES CAUSE METABOLIC REPROGRAMMING AND ELICIT UNIQUE VULNERABILITIES IN PRECLINICAL MODEL SYSTEMS OF GLIOBLASTOMA

The purpose of this study is to improve the efficacy of imipridones, a novel class of AKT/ERK inhibitors. The lead compound ONC201 has entered clinical testing for glioblastoma (GBM) and recently chemically modified imipridones, ONC206 and ONC212, have been designed. Transcriptome, untargeted liquid...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Ishida, Chiaki, Zhang, Yiru, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Prabhu, Varun Vijay, Allen, Joshua, Siegelin, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216202/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.411
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