Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and elicits Synthetic Lethality in Glioblastoma

PURPOSE: Glioblastoma remain a challenge in oncology in part due to tumor heterogeneity. EXPERIMENTAL DESIGN: Patient-derived xenograft and stem-like glioblastoma cells were used as the primary model systems. RESULTS: Based on a transcriptome and subsequent gene set enrichment analysis (GSEA), we sh...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Zhang, Yiru, Ishida, Chiaki Tsuge, Ishida, Wataru, Lo, Sheng-Fu L., Zhao, Junfei, Shu, Chang, Bianchetti, Elena, Kleiner, Giulio, Sanchez-Quintero, Maria J., Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Canoll, Peter, Siegelin, Markus D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095717/
https://ncbi.nlm.nih.gov/pubmed/29764852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0260
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