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Hsp60 REGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE IN TUMOR CELLS

Mitochondrial apoptosis plays a critical role in tumor maintenance and dictates the response to therapy, in vivo, but the regulators of this process are still largely elusive. Here, we show that the molecular chaperone Heat Shock Protein-60 (Hsp60) directly associates with cyclophilin D (CypD), a co...

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Autors principals: Ghosh, Jagadish C., Siegelin, Markus D., Dohi, Takehiko, Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982903/
https://ncbi.nlm.nih.gov/pubmed/20978188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2225
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