Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma

Malignant gliomas display high levels of the transcription factor c-myc and organize a tumor specific chaperone network within mitochondria. Here, we show that c-myc along with mitochondrial chaperone inhibition displays massive tumor cell death. Inhibition of mitochondrial matrix chaperones and c-m...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ishida, Chiaki Tsuge, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Altieri, Dario C., Karpel-Massler, Georg, Siegelin, Markus David
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514897/
https://ncbi.nlm.nih.gov/pubmed/28415755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16202
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