Cytotoxicity of Tumor Antigen Specific Human T Cells Is Unimpaired by Arginine Depletion

Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase. It is generally assumed that this arginine deficiency induces a global shut-down of T cell activation with ensuing tumor immune escape. W...

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Main Authors: Munder, Markus, Engelhardt, Melanie, Knies, Diana, Medenhoff, Sergej, Wabnitz, Guido, Luckner-Minden, Claudia, Feldmeyer, Nadja, Voss, Ralf-Holger, Kropf, Pascale, Müller, Ingrid, Conradi, Roland, Samstag, Yvonne, Theobald, Matthias, Ho, Anthony D., Goldschmidt, Hartmut, Hundemer, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662698/
https://ncbi.nlm.nih.gov/pubmed/23717444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063521
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