Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

In the tumor microenvironment, arginine is metabolized by arginase-expressing myeloid cells. This arginine depletion profoundly inhibits T cell functions and is crucially involved in tumor-induced immunosuppression. Reconstitution of adaptive immune functions in the context of arginase-mediated tumo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Werner, Anke, Koschke, Miriam, Leuchtner, Nadine, Luckner-Minden, Claudia, Habermeier, Alice, Rupp, Johanna, Heinrich, Christin, Conradi, Roland, Closs, Ellen I., Munder, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523021/
https://ncbi.nlm.nih.gov/pubmed/28791021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00864
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