Cytotoxicity of Tumor Antigen Specific Human T Cells Is Unimpaired by Arginine Depletion

Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase. It is generally assumed that this arginine deficiency induces a global shut-down of T cell activation with ensuing tumor immune escape. W...

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Main Authors: Munder, Markus, Engelhardt, Melanie, Knies, Diana, Medenhoff, Sergej, Wabnitz, Guido, Luckner-Minden, Claudia, Feldmeyer, Nadja, Voss, Ralf-Holger, Kropf, Pascale, Müller, Ingrid, Conradi, Roland, Samstag, Yvonne, Theobald, Matthias, Ho, Anthony D., Goldschmidt, Hartmut, Hundemer, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662698/
https://ncbi.nlm.nih.gov/pubmed/23717444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063521
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