DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCF(β-TRCP) as a novel E3 ligase that targets Mdm2 for ubiquitination and destruction in a Casein Kinas...

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Bibliographic Details
Main Authors: Wang, Zhiwei, Inuzuka, Hiroyuki, Zhong, Jiateng, Fukushima, Hidefumi, Wan, Lixin, Liu, Pengda, Wei, Wenyi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2012
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660052/
https://ncbi.nlm.nih.gov/pubmed/22976441
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