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Elevated Nuclear Factor Erythroid-2 Levels Promote Epo-Independent Erythroid Maturation and Recapitulate the Hematopoietic Stem Cell and Common Myeloid Progenitor Expansion Observed in Polycythemia Vera Patients

The molecular etiology of polycythemia vera (PV) remains incompletely understood. Patients harbor increased numbers of hematopoietic stem cells and display Epo-independent erythroid maturation. However, the molecular mechanism underlying Epo hypersensitivity and stem cell expansion is unclear. We ha...

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Main Authors: Bogeska, Ruzhica, Pahl, Heike L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: AlphaMed Press 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659758/
https://ncbi.nlm.nih.gov/pubmed/23341442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0046
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